Connectivity Map. Connectivity map of interactions among genes differently expressed To build a Connectivity Map, the Broad brings together molecular biologists, genomics specialists, computational scientists, pharmacologists, chemists and chemical biologists, as well as expertise from across the breadth and depth of. The ultimate objective of biomedical research is to connect human diseases with the genes that underlie them and drugs that treat them
Frontiers Master Regulators Connectivity Map A Transcription Factors from www.frontiersin.org
The Research Article "The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease" (29 Sept We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs
Frontiers Master Regulators Connectivity Map A Transcription Factors
But this remains a daunting task, and even the most inspired researchers still have to resort to laborious screens of genetic or chemical libraries. These are the questions the Connectivity Map project set. 摘要：Connectivity Map 是药物基因组学研究领域的重要数据库，是 计算生物学 和药物筛选研究人员做研究时不得不重视的数据库。 它不仅提供大量宝贵的药物处理人类细胞系前后的基因表达谱数据，而且也提供了基于 模式匹配算法 的在线工具，用户提交合适的基因列表就能得到该数据库中与之相关.
Premium Photo US Digital Connectivity Map Cyber Tech and Data Flow. The Research Article "The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease" (29 Sept The Connectivity Map is a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and simple pattern-matching algorithms that together enable the discovery of decisive functional connections between drugs, genes, and diseases
A map of functional connectivity in the brain computed with the support. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high-throughput reduced representation. We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures